A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection
This comprehensive review synthesizes evidence on the multi-organ, systemic effects of SARS-CoV-2 infection, detailing how the virus disrupts whole-body metabolism, dysregulates the immune and endocrine systems, and leads to widespread organ damage. These findings are crucial for understanding both acute COVID-19 and its long-term sequelae (PASC), with implications for managing astronaut health during space missions.